Colloidal Gold Nanoparticles (AuNPs) have been utilized for centuries by artists due to the vibrant colors produced by their interaction with visible light.
Colloidal gold is a sol or colloidal suspension of nanoparticles of gold in a fluid, usually water. The colloid is usually either an intense red colour for spherical particles less than 100 nm or blue/purple for larger spherical particles or nanorods. The field of Gold Nanoparticles applications is increasing day by day due to its strong adsorption, high biocompatibility, and large surface area-to-volume ratio.
The optical and electronic properties of gold nanoparticles are tunable by changing the size, shape, surface chemistry, or aggregation state.
Application Areas : More recently, these unique optoelectronic properties have been researched and utilized in high technology applications such as biomedical applications, therapeutic agent delivery, photodynamic therapy, diagnostics, electrochemical applications, electronics, sensors, probes and catalysis.
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In a cell population, each cell exhibits distinct variations at biomolecular level. In the analysis of a large heterogeneous population, major characteristics of cells may mask the minor characteristics of abnormalities. To overcome this limitation, single-cell analysis, where molecular information can be collected at the individual cell level, has emerged in many fields such as biomedical research and cancer biology.
Several single-cell analysis approaches such as comet assay, DNA sequencing, single-cell PCR, flow cytometry, and mass spectrometry were developed. Other techniques including atomic force microscopy and fluorescence microscopy are still being evaluated for the goal.
Dense brush conformation-bearing theranostic agents are emerging as drug delivery systems due to their higher ability to escape from reticuloendothelial system uptake which prolongs their in vivo circulation time. With the aim of developing dual therapy agent, 13-nm gold nanoparticles' surfaces were coated with different amounts of polyethylene glycol to obtain dense brush conformation-bearing theranostic agents.
Among the different theranostic agent candidates prepared, the most promising candidate was selected based on structural conformation, stability, size, zeta potential, hemocompatibility, cell inhibition, and cell death pathway towards MCF-7 cell line.
Cancer is one of the most common causes of human deaths worldwide. Nanotechnology has the potential to facilitate the detection, diagnosis, and treatment of cancer cases. Successful delivery of nucleic acids into cancer cells with the use of nanoparticles would be a significant improvement for medical and cellular biology.
Gold nanoparticles have been suggested as therapeutic delivery tools for cancer. Because microRNAs, which induce post-transcriptional gene silencing, are deregulated in cancer cells, they are also considered as strong candidates for cancer therapy applications.
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